"目录号: HY-14478
Cell Cycle/DNA DamageEpigenetics-
UPF 1069是PARP2选择性抑制剂，IC50为0.3 μM，比对PARP1的抑制性高27倍。
相关产品
Olaparib-BMN-673-MK-4827-XAV-939-Rucaparib phosphate-Nicotinamide-PJ34 hydrochloride-Veliparib dihydrochloride-NVP-TNKS656-AZD-2461-E7449-BSI-201-G007-LK-INO-1001-A-966492-
生物活性
Description
UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM; ~27-fold selective against PARP1.IC50 Value: 0.3 μMTarget: PARP2in vitro: In organotypic hippocampal slices, PARP-2 inhibition with UPF-1069 (0.01-1 micromolxL(-1)) caused a concentration-dependent exacerbation (up to 155%) of OGD-induced CA1 pyramidal cell death. Higher concentrations, acting on both PARP-1 and PARP-2, had no effect on OGD injury [1].in vivo: In organotypic hippocampal slices, PARP-2 inhibition with UPF-1069 (0.01-1 mM) causes a concentration-dependent exacerbation (up to 155%) of oxygen-glucose deprivation (OGD)-induced CA1 pyramidal cell death. Higher concentrations, acting on both PARP-1 and PARP-2, have no effect on OGD injury. In mouse mixed cortical cells exposed to OGD, UPF-1069 (1-10 mM) significantly reduces post-ischaemic damage.Clinical trial: N/A
References
