最近有关“相变”或“相分离”（Phase separation）的文章不断地出现在CNS杂志上，一个新的比较火的领域。
- 控制RNA结合蛋白相分离的驱动力的机制研究
A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins
Cell. 26 July 2018
https://doi.org/10.1016/j.cell.2018.06.006
- 相分离与基因转录存在密切关联
Imaging dynamic and selective low-complexity domain interactions that control gene transcription.
Science, 27 Jul 2018, 361(6400):eaar2555,
doi:10.1126/science.aar2555.
Coactivator condensation at super-enhancers links phase separation and gene control.
Science, 27 Jul 2018, 361(6400):eaar3958,
doi:10.1126/science.aar3958.
Mediator and RNA polymerase II clusters associate in transcription-dependent condensates.
Science, 27 Jul 2018, 361(6400):412-415,
doi:10.1126/science.aar4199.
Dynamic condensates activate transcription.
Science, 27 Jul 2018, 361(6400):329-330,
doi:10.1126/science.aau4795.
- 核内“液-液相分离”对染色质结构的感知与重塑
Liquid Nuclear Condensates Mechanically Sense and Restructure the Genome
DOI：https://doi.org/10.1016/j.cell.2018.10.057
- 超级增强子通过相分离调控基因表达
- Wilson, E.B., THE STRUCTURE OF PROTOPLASM. Science, 1899. 10(237): p. 33-45.
- Li, P., et al., Phase transitions in the assembly of multivalent signalling proteins. Nature, 2012. 483(7389): p. 336-40.
- Kato, M., et al., Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels. Cell, 2012. 149(4): p. 753-67.
- Jiang, H., et al., Phase transition of spindle-associated protein regulate spindle apparatus assembly. Cell, 2015. 163(1): p. 108-22.
- Brangwynne, C.P., et al., Germline P granules are liquid droplets that localize by controlled dissolution/condensation. Science, 2009. 324(5935): p. 1729-32.
- Whyte, W.A., et al., Master transcription factors and mediator establish super-enhancers at key cell identity genes. Cell, 2013. 153(2): p. 307-19.
- Hnisz, D., et al., Super-enhancers in the control of cell identity and disease. Cell, 2013. 155(4): p. 934-47.
- Hnisz, D., et al., A Phase Separation Model for Transcriptional Control. Cell, 2017. 169(1): p. 13-23.
- Sabari, B.R., et al., Coactivator condensation at super-enhancers links phase separation and gene control. Science, 2018.
