Palovarotene

"目录号: HY-14800

Anti-infection-

Radezolid 是一种恶唑烷酮类抗生素。

Bacterial

相关产品

G-418 disulfate-Anisomycin-Salinomycin-Avibactam sodium-Vancomycin hydrochloride-Hygromycin B-Bleomycin sulfate-Ciprofloxacin-Minocycline hydrochloride-Ampicillin sodium-Tetracycline hydrochloride-Tebipenem-Kanamycin sulfate-Solithromycin-Tedizolid-

生物活性

Description

Radezolid is a novel oxazolidinone antibiotic agent.

In Vitro

Radezolid MICs are systematically equal to or lower (up to 3 log2 dilutions) than those of linezolid for all linezolid-susceptible strains, with an 8-fold difference for the linezolid-resistant strains. Radezolid shows a greater potency than linezolid, independent of the bacteria tested, when concentrations are expressed on a weight (mg/L) basis. Radezolid shows an improved potency compared to that of linezolid when concentrations are expressed on a weight (mg/L) basis[1]. Radezolid and TR-700 perform well against 3-copy G2447T, G2576T, and G2576T/T2571C mutants[2].

Clinical Trial

NCT00640926

Melinta Therapeutics, Inc.

Community-Acquired Pneumonia (CAP)

October 2007

Phase 2

NCT00646958

Melinta Therapeutics, Inc.

Infectious Skin Diseases-Bacterial Skin Diseases-Staphylococcal Skin Infections-Streptococcal Infections-Abscess

December 2007

Phase 2

View MoreCollapse

References

[1].Lemaire S, et al. Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila.

[2].Locke JB, et al. Structure-activity relationships of diverse oxazolidinones for linezolid-resistant Staphylococcus aureus strains possessing the cfr methyltransferase gene or ribosomal mutations. Antimicrob Agents Chemother. 2010 Dec;54(12):5337-43.

推荐阅读更多精彩内容

  • “生死契阔,与子成说,执子之手,与子偕老。”一直以来都很喜欢《诗经》中的这句话,喜欢那种“愿得一人心,白首不分离”...
    夕乐阅读 1,103评论 0 4
  • 我想,对很多女孩子而言,这个世界上最幸福的事情,莫过于嫁给自己喜欢的人。爱情,是个属灵的话题,婚礼,又是这样庄严而...
    林泉儿阅读 90评论 0 0
  • 之前写了jenkins的安装和安全配置,今天这篇文章主要是关于php的持续集成测试环境的配置。 安装jenkins...
    zigo阅读 3,896评论 0 9
  • 朋友圈中一对情侣在沙滩上拍下视频,那个沙滩在朕成功像的脚下,在四十四桥的尽头,她在鼓浪屿,记忆中的好时光。 好时光...
    1c62b78b2c5c阅读 456评论 2 4